Претрага
4 items
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Regional Slope Stability Analysis in Landslide Hazard Assessment Context, North Macedonia Example
Miloš Marjanović, Biljana Abolmasov, Igor Peshevski, James Reeves, Irena Georgievska. "Regional Slope Stability Analysis in Landslide Hazard Assessment Context, North Macedonia Example" in Understanding and Reducing Landslide Disaster Risk, Springer International Publishing (2020). https://doi.org/10.1007/978-3-030-60227-7_29
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Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach
Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188
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Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study
Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study" in European Journal of Pharmaceutical Sciences, Elsevier BV (2023). https://doi.org/10.1016/j.ejps.2023.106557
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High-cellulose content of in-situ Miocene fossil tree stumps and trunks from Lusatia lignite mining district, Federal Republic of Germany
Jolanta Kus, Martina Dolezych, Wilfrid Schneider, James C. Hower, Tamas Hofmann, Ezster Visiné Rajczi, Andras Bidló, Bernadett Bolodár-Varga, Reinhard F. Sachsenhofer, Achim Bechtel, Ksenija Stojanović, Dragana Životić, Ivan Kojić, Maria Mastalerz, Torsten Graupner, Wiliam E. Lukens, Lloyd Donaldson (2024)Second Miocene Seam Complex (2nd MFK; germ.: 2. Mioz¨aner Fl¨ozkomplex) holds many in-situ, not permineralised fossil tree stumps and trunks with high-cellulose contents. The state of preservation of a set of in-situ fossil trees (Taxodioxylon cryptomerioides, Sciadopityoxylon wettsteinii, and Quasisequoioxylon piskowitzense) collected from three open-cast mines (Welzow-Süd, Meuro, and Piskowitz) in Lusatia lignite mining district, Federal Republic of Germany was investigated using a multi-method research schema. Examination of preservation state of thermally immature fossil woods revealed: (1) well-preserved (non-deformed, ...ксилит, холоцелулоза, фосилно и модерно дрво, други слој лужичког лигнита, лигнит, ЦЛСМ, ЦЛСМ обојен калкофлуором, микро-ФТИР, биомаркери, изотопи угљеникаJolanta Kus, Martina Dolezych, Wilfrid Schneider, James C. Hower, Tamas Hofmann, Ezster Visiné Rajczi, Andras Bidló, Bernadett Bolodár-Varga, Reinhard F. Sachsenhofer, Achim Bechtel, Ksenija Stojanović, Dragana Životić, Ivan Kojić, Maria Mastalerz, Torsten Graupner, Wiliam E. Lukens, Lloyd Donaldson. "High-cellulose content of in-situ Miocene fossil tree stumps and trunks from Lusatia lignite mining district, Federal Republic of Germany" in International Journal of Coal Geology, Elsevier BV (2024). https://doi.org/10.1016/j.coal.2024.104494