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Упит dcterms_creator_txt:Vladimir D. Dobričić

1190 items

  • Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach

    Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)
    Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...
    pyrazoloquinolinones, nanocrystals, wet media milling, fasted/fed bioavailability
    ... Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić Дигитални репозиторијум Рударско-геолошког факултета Универзитета у Београду [ДР РГФ] ...
    ... Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić | Pharmaceutics | 2021 | | 10.3390/pharmaceutics13081188 http://dr.rgf.bg.ac.rs/s/repo/ ...
    ... Divović-Matović 2, Daniel E. Knutson 3 , Jelena B. Ðoković 1, Aleksandar Kremenović 4 , Vladimir D. Dobričić 5, Danijela V. Randjelović 6, Ivana Pantelić 1 , James M. Cook 3 , Miroslav M. Savić 2 and Snežana D. Savić 1,* ���������� ������� Citation: Mitrović, J.R.; Divović-Matović, B.; Knutson ...

  • Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study

    Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)
    Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...
    Pharmaceutical Science
    ... to JC). The authors would also like to thank Mr. Klaus Weyhing, Department of Pharmaceutical Technology at Uni- versity of Tubingen and dr Vladimir Dobričić, Department of Pharma- ceutical Chemistry, University of Belgrade – Faculty of Pharmacy for their experimental assistance. Supplementary ...
    ... Pharm. Sci. 87 (8), 931–935. https://doi.org/10.1021/js980001d. 'Knutson, D.E., Kodali, R., Divović, B., Treven, M., Stephen, M.R., Zahn, N.M., Dobričić, V., Huber, A.T., Meirelles, M.A., Verma, R.S., et al., 2018. Design and synthesis of novel deuterated ligands functionally selective for the y- ...
    ... 254–263. https://doi.org/10.1016//j.ijpharm.2019.05.065. Mitrović, J.R., Divović, B., Knutson, D.E., Đoković, J.B., Vulić, P.J., Randjelović, D.V., Dobričić, V.D., Čalija, B.R., Cook, J.M., Savić, M.M., Savić, S.D., 2020. Nanocrystal dispersion of DK-I-56-1, a poorly soluble pyrazoloquinolinone positive ...

  • Rezultati probnog ispitivanja geotehničkih prenapregnutih sidara u Užicu (Stari grad)

    Vladimir Kovačević (2024)
    Za potrebe izrade završnog rada na četvrtoj godini Rudarsko-geološkog fakulteta, studijskog programa Geotehnika, pod mentorstvom doc. dr Zorana Berisavljevića, odabrana je tema „Rezultati probnog ispitivanja geotehničkih prenapregnutih sidara u Užicu (Stari grad)“. Osnovni metodološki pristup koji je korišćen za rešavanje postavljenog problema predstavlja kabinetsko istraživanje dostupne dokumentacije, analiza i interpretacija rezultata izvedenih geoloških,geotehničkih i geomehaničkih istraživanja. Predstavljene su osnovne informacije,karakteristike i upotreba prednapregnutih geotehničkih sidara.Analiziran je tok testiranja granične nosivosti prednapregnutih sidara. Na osnovu izvršenih geotehničkih istraživanja terena i ispitivanja ...
    geotehnička istraživanja, prednapregnuta sidra, nosivost sidra, standard SIA V 191
    ... ih prenapregnutih sidara u Užicu (Stari grad) Vladimir Kovačević Дигитални репозиторијум Рударско-геолошког факултета Универзитета у Београду [ДР РГФ] Rezultati probnog ispitivanja geotehničkih prenapregnutih sidara u Užicu (Stari grad) | Vladimir Kovačević | | 2024 | | http://dr.rgf.bg.ac.rs ...
    ... ? L L / L L S O A I S O N M N N O I N V ? H D .LSŠLL – V M V G I S O f N V A L L I d S I T W O N T O H . L N O N M O M I N S I d V Z ĐNISSHNH.LSHNHd G N V SMMn.LOnbiLLS H O N O L I N M O - H r N V Z H N H d V N G H H 4 d I W F I O Ž T ? L L S N O N M VZ M V . L ...
    ... Golsvordijeva 36, B e o g r a d Projektant: U N I V E R Z I T E T U B E O G R A D U , R U D A R S K O - G E O L O Š K I F A K U L T E T Beograd, Đ u š i n a 7 Tehnička dokumentacija: G E O T E H N I Č K I E L A B O R A T ZA P O T R E B E I Z G R A D N J E P E Š A Č K O G ...

  • Komparativna analiza hidroloških režima rijeke Gline, Korane i D. Mrežnice s aspekta hidrogeoloških značajki porječja

    Vladimir Jurak (1983)
    Hidrološki režim, hidrogeologija, Korana

  • Хидрогеолошке карактеристике изворишта за водоснабдевање Kањиже

    Vladimir Jović ( 2024)
    Rad se bavi hidrogeoloskim karakteristikama izvorista za vodosnabdevanje opstine Kanjiza. Istrazivanja su sprovedena na tri hidrogeoloska kompleksa, od kojih su drugi i treći kompleks kljućni za vodosnabdevanje. Ovi kompleksi se nalaze u sedimentima pleistoćenske i paludinske starosti, na dubinama od 60 do 260 metara, sa subarteskim nivoom vode. Ukupne rezerve podzemnih voda u okviru drugog i treć eg hidrogeoloskog kompleksa iznose 935 l/s, a klasifikovane su u dve kategorije: B i C1. Kvalitet podzemnih voda je stabilan i pripada ...
    hidrogeologija, podzemne vode, vodosnabdevanje, hidrogeološki kompleksi, Kanjiža
    ... Хидрогеолошке карактеристике изворишта за водоснабдевање Kањиже Vladimir Jović Дигитални репозиторијум Рударско-геолошког факултета Универзитета у Београду [ДР РГФ] Хидрогеолошке карактеристике изворишта за водоснабдевање Kањиже | Vladimir Jović | | 2024 | | http://dr.rgf.bg.ac.rs/s/repo/item/0009045 ...
    ... ZA HIDROGEOLOGIJU ZAVRŠNI RAD: HIDROGEOLOŠKE KARAKTERISTIKE IZVORIŠTA ZA VODOSNABDEVANJE KANJIŽE Mentor Student Prof. Dr Dušan Polomčić Vladimir Jović G76/21 Završni rad: Hidrogeološke karakteristike izvorišta za vodosnabdevanje Kanjiže Komisija: 1. Prof.dr Dušan Polomčić Rudarsko-geološki ...
    ... l/s (Rakić D., Pavlovski V i Petrović V: 2020.) 35 ——III Xr koMnnekc 3axBaheHe konMuMHe | —— cpe/Mbe 3axBaheHe koO/nMuWMHe III rR 30 Slika 8. Grafički prikaz zahvaćenih količina podzemnih voda iz III hidrogeološkog kompleksa ha izvorištu Kanjiža u analizirahom periodu u l/s (Rakić D., Pavlovski ...

  • Izučavanje procesa okrupnjavanja mlevenog krečnjakak radi primene u poljoprivredi

    Vladimir D. JOVANOVIĆ (2016)
    litotamnijski krešnjak, bentonit, pelet, rol-presa, mehaniške osobine briketa i peleta

  • Discussion of „Classroom activities to illustrate concepts of Darcy’s law and hydraulic conductivity“ by Roseanna M.Neupauer and Norman D. Dennis

    Brkić Dejan, Mitrović Vladimir (2010)

  • Mikroorganizmi - biohidrogeološki indikatori odabranih pojava mineralnih voda Srbije

    Vladimir Šaraba (2021)
    Sa namerom definisanja hidrogeološke uloge i značaja mikrobiološkog diverziteta odabranih pojava mineralnih voda Srbije, primenom sistema biodetektora, dokazano je prisustvo gvožđevitih, sulfato-redukujućih, sluz-produkujućih, heterotrofnih aerobnih i denitrifikacionih bakterija, na osnovu čega je proračunat rizik od razvoja procesa biokorozije i biohemijske inkrustacije, te zdravstveni rizik. Uz procenu rizika, izvedene su analize skenirajuće elektronske mikroskopije biofilmova i hidrogeohemijsko modeliranje, te makroskopska, otpička i difrakciona ispitivanja naslaga inkrustacije, dok je fizičko-hemijskim analizama utvrđena vrednost ukupne mineralizacije iznad 1 g/L, kao i povišeni ...
    biohidrogeologija, SEM analize, makroskopska i optička ispitivanja, rendgenska difrakcija praha, hidrogeohemijsko modeliranje, BART analize, metabarkoding analize mikrobioma, fizičko-hemijske analize, starenje bunara (biokorozija, biohemijska inkrustacija i biozarastanje), zdravstveni rizik
    ... indikatori odabranih pojava mineralnih voda Srbije Vladimir Šaraba Дигитални репозиторијум Рударско-геолошког факултета Универзитета у Београду [ДР РГФ] Mikroorganizmi - biohidrogeološki indikatori odabranih pojava mineralnih voda Srbije | Vladimir Šaraba | | 2021 | | http://dr.rgf.bg.ac.rs/s/re ...
    ... Vladimir S. Šaraba MIKROORGANIZMI – BIOHIDROGEOLOŠKI INDIKATORI ODABRANIH POJAVA MINERALNIH VODA SRBIJE doktorska disertacija Beograd, 2021. UNIVERSITY OF BELGRADE FACULTY OF MINING AND GEOLOGY Vladimir S. Šaraba ...
    ... 7 (1869), 1-14. Tian, R., Ning, D., He, Z., Zhang, P., Spencer, S. J., Gao, S., Shi, W., Wu, L., Zhang, Y., Yang, Y., Adams, B. G., Rocha, A. M., Detienne, B. L., Lowe, K. A., Joyner, D. C., Klingeman, D. M., Arkin, A. P., Fields, M. W., Hazen, T. C., Stahl, D. A., Alm, E. J., & Zhou, J. (2020) ...

  • Determination of Mechanical Properties of Altered Dacite by Laboratory Methods

    Veljko Rupar, Vladimir Čebašek, Vladimir Milisavljević, Dejan Stevanović, Nikola Živanović (2021)
    This paper presents a methodology for determining the uniaxial and triaxial compressive strength of heterogeneous material composed of dacite (D) and altered dacite (AD). A zone of gradual transition from altered dacite to dacite was observed in the rock mass. The mechanical properties of the rock material in that zone were determined by laboratory tests of composite samples that consisted of rock material discs. However, the functional dependence on the strength parameter alteration of the rock material (UCS, intact ...
    Geology, Geotechnical Engineering, Engineering Geology
    ... of Altered Dacite by Laboratory Methods Veljko Rupar 1,*, Vladimir Čebašek 1 , Vladimir Milisavljević 1, Dejan Stevanović 1 and Nikola Živanović 2 ���������� ������� Citation: Rupar, V.; Čebašek, V.; Milisavljević, V.; Stevanović, D.; Živanović, N. Determination of Mechanical Properties ...
    ... Rupar, Vladimir Čebašek, Vladimir Milisavljević, Dejan Stevanović, Nikola Živanović Дигитални репозиторијум Рударско-геолошког факултета Универзитета у Београду [ДР РГФ] Determination of Mechanical Properties of Altered Dacite by Laboratory Methods | Veljko Rupar, Vladimir Čebašek, Vladimir Milisavljević ...
    ... com/journal/minerals minerals Article Determination of Mechanical Properties of Altered Dacite by Laboratory Methods Veljko Rupar 1’*, Vladimir Ceba’ek 1, Vladimir Milisavljevié 1, Dejan Stevanovié 1 and Nikola Zivanovié ” Mining Department, Mining and Geology Faculty, University of Belgrade, 11000 ...

  • Pregled povreda u rudnicima Javnog Preduzeća za Podzemnu Eksploataciju Uglja, u periodu 2011-2015.

    Milisavljević Vladimir, Milinković D., Cvjetić Aleksandar (2017)

  • Arhitektonsko-građevinski kamen Crne Gore, stanje i potencijali

    Darko Božović, Vladimir Simić (2023)
    arhitektonsko-građevinski kamen, rezerve, kvalitet, potencijalnost

  • Pelletization of fly ash and application areas

    Tomanec Rudolf, Birčević D, Simović I, Čebašek Vladimir (2011)

  • Towards Better Valorisation of Industrial Minerals andRocks in Serbia—Case Study of Industrial Clays

    Vladimir Simić, Dragana Životić, Zoran Miladinović (2021)
    Management, Monitoring, Policy and Law,Nature and Landscape Conservation
    ... Study of Industrial Clays Vladimir Simić, Dragana Životić, Zoran Miladinović Дигитални репозиторијум Рударско-геолошког факултета Универзитета у Београду [ДР РГФ] Towards Better Valorisation of Industrial Minerals andRocks in Serbia—Case Study of Industrial Clays | Vladimir Simić, Dragana Životić ...
    ... www.mdpi.com/journal/resources Review Towards Better Valorisation of Industrial Minerals and Rocks in Serbia—Case Study of Industrial Clays Vladimir Simić *, Dragana Životić and Zoran Miladinović Faculty of Mining and Geology, University of Belgrade, Djusina 7, 11000 Belgrade, Serbia; dragana ...
    ... April 2021). 31. Simić, V.; Životić D. Geological modelling of clay deposits as a basis for open pit designs. In Proceedings of the I Conference on Surface Clay Exploitation, Kanjiža, Serbia, 29 June–2 July 1995; pp. 197–199. 32. Simić, V.; Đurić, S.; Životić, D. Bentonitic Clays of the Drmno Deposit ...

  • Mineral Resources of Serbia: Environmental, Societal and Economic Challenges

    Vladimir Simić, Rade Jelenković, Dragana Životić (2019)
    ... Ksenija, Gržetić, Ivan, Jovančićević, Branislav, Cvetković, Olga, Šajnović, Aleksandra, Simić, Vladimir, Stojaković Rajko and Scheeder, Georg. 2013. “Petrological and geochemical composition of lignite from the D field, Kolubara basin (Serbia).” Infernational Journal of Coal Geology 111:5-22. Reviewed ...
    ... ry Contributor Copy 54 Vladimir Simić, Rade Jelenković and Dragana Životić BIOGRAPHICAL SKETCHES Vladimir Simić, PhD Professor Affiliation: Faculty of Mining and Geology, University of Belgrade, Serbia Contact: vladimir.simic(orgf.bg.ac.rs Education: Vladimir Simić graduated in 1987 at ...
    ... , Societal and Economic Challenges Vladimir Simić, Rade Jelenković, Dragana Životić Дигитални репозиторијум Рударско-геолошког факултета Универзитета у Београду [ДР РГФ] Mineral Resources of Serbia: Environmental, Societal and Economic Challenges | Vladimir Simić, Rade Jelenković, Dragana Životić ...

  • Application of the Fuzzy Model in the Evaluation and Selection of Hydraulic Excavators on Open-Pit Lignite Mine

    Stevan Đenadić, Miloš Tanasijević, Vladimir Milisavljević, Dragan Ignjatović, Predrag Jovančić (2021)
    The production of lignite in large open-pit mines is mainly performed with continuously operating equipment, where bucket-wheel excavators, bucket-chain excavators, belt conveyors, and spreaders are the basic machines. Smaller machines, usually of discontinuous operating nature, are commonly categorized as auxiliary machines. This paper presents the research related to the analysis of auxiliary machine parameters with the case study for a hydraulic excavator. The purpose of the analysis was to develop a model of rating quality of service of the ...
    Fuzzy theory, hydraulic excavator, selection, quality of service, asset management

  • Rezultati ispitivanja parametara čvrstoće i dinamičkih svojstava mermera i mogućnost njihove korelacije

    Jelena Majstorović-Necković, Vladimir Čebašek, Veljko Rupar (2023)
    Ispitivanja stena kao radne sredine, odnosno materijala sa kojim se gradi, na kome se gradi i u kome se gradi, svojom složenošću zahteva njeno svestrano izučavanje po velikom broju parametara. Zadatak Mehanike stena je da što bolje upozna ponašanje stenske mase i njenu otpornost na dejstvo pritiska, zatezanja i smicanja, kao i dinamičkih svojstava. Poznavanje navedenih parametara i njihova korelacija omogućavaju pouzdaniji izbor parametara za projektovanje danas sve zahtevnijih uslova kako podzemne, tako i površinske eksploatacije. U ovom radu ...
    mermer, jednoosna čvrstoća na pritisak, čvrstoća na istezanje, brzina longitudinalnih elastičnih talasa, korelacija

  • Underground loading-haulage equipment selection with application of topsis method with different weighting methods of criteria

    Vladimir Krivošić, Luka Crnogorac, Rade Tokalić (2024)
    The choice of adequate mining machines is one of the most complex problems in the underground exploitation of mineral raw materials. The weight of such a decision is reflected in the high prices of these machines and the occurrence of even greater costs during their use if their choice was wrongly conceived. There are numerous examples from practice in which such decisions were made solely on the basis of comparing the prices of machines, without considering any of the ...
    utovarno-transportna mehanizacija, izbor, TOPSIS, entropija, standardna devijacija, težina kriterijuma

  • Prognozna ocena resursa kaolinitskih glina u sedimentnim basenima Srbije

    Vladimir M. Simić (2003)
    Kaolinitske gline predstavljaju jednu od privredno najznačajnijih nemetaličnih mineralnih sirovina u Srbiji. Ležišta tih glina odavno se istražuju i eksploatišu u Aranđelovačkom i Kolubarskom basenu i basenima vlašićkog antiklinorijuma. Osim toga, u većem ili manjem obimu istražene su mnoge lokalnosti, a na nekima od njih vršila se povremena eksploatacija. Dosadašnja istraživanja kaolinitskih glina imala su, međutim, prevashodno uzak istraživački cilj - utvrđivanje rezervi glina određenog ležišta, dok su istraživanja regionalnog karaktera bila malog obima i vezana za delove pojedinih ...
    prognozna ocena, resursi kaolinitskih glina, sedimentni baseni, Srbija, geologija, mineralogija, kvalitet, potencijalnost

  • Long-term planning methodology for improving wood biomass utilization

    Vladimir Vukašinović, Dušan Gordić, Marija Živković, Davor Koncalović, Dubravka Živković (2019)
    The insufficiently developed forest management system is often followed by undeveloped forest resources supply chain and insufficient institutional support. These cause inefficient usage of fuel-wood as well as huge amounts of unused forest residues. In order to achieve optimal and long-term sustainable utilisation of biomass, an original methodology based on the interaction of mathematical optimization and backcasting approach has been developed. Mathematical optimization is used for both generation and consideration of techno-economic parameters of the forest biomass supply chain. ...
    Long-term planning methodology, Forest biomass, MINLP, Backcasting

  • Development of integrated fuzzy model for mine management optimization

    Miodrag Čelebić, Sanja Bajić, Dragoljub Bajić, Dejan Stevanović, Duško Torbica, Vladimir Malbašić (2023)
    fuzzy logika, višekriterijumsko odlučivanje, ocenjivanje eksperata
    ... Duško Torbica, Vladimir Malbašić Дигитални репозиторијум Рударско-геолошког факултета Универзитета у Београду [ДР РГФ] Development of integrated fuzzy model for mine management optimization | Miodrag Čelebić, Sanja Bajić, Dragoljub Bajić, Dejan Stevanović, Duško Torbica, Vladimir Malbašić | Comptes ...
    ... TEGRATED FUZZY MODEL FOR MINE MANAGEMENT OPTIMIZATION Miodrag Čelebić*, Sanja Bajić**, Dragoljub Bajić***", Dejan Stevanović**, Duško Torbica*, Vladimir Malbašić* Received on April 5, 2023 Presented by Ch. Roumenin, Member of BAS, on June 27, 2023 Abstract Technoeconomic, environmental and ...
    ... triangular fuzzy number, the fuzzy synthetic extent is calculated using; the following; equation: m i n m -1 m m m 1 1 1 S -Ž MLe|.2.MA, |Ž,D-> 552 d|| _—R — L — j=1 i=1 j=1 jel jcl je1 Mdj XOsj M i=l i=l i=1 Step 3. The degree of possibility of two triangular fuzzy numbers is deter- mined ...