Претрага
513 items
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Malathion-induced inhibition of human plasma cholinesterase studied by the fluorescence spectroscopy method
The in vitro effect of technical grade malathion was assessed via the kinetic parameters of human plasma butyrylcholinesterase (BChE) using N-methylindoxyl acetate as a substrate for BChE. An inhibitor kinetics study demonstrated the existence of a biphasic inhibition curve, indicating high- and low-affinity binding sites of malathion. The IC50 values as calculated from the experimental inhibition curves were 1.33 × 10–9 and 1.48 × 10–5 M for the high- and low-affinity binding sites, respectively; Hill’s analysis gave 1.29 × ...V. M. Pavelkić, K. S. Krinulović, J. Z. Savić, M. A. Ilić. "Malathion-induced inhibition of human plasma cholinesterase studied by the fluorescence spectroscopy method" in Russian Journal of Physical Chemistry A, Pleiades Publishing Ltd (2008). https://doi.org/10.1134/S0036024408050312
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Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study
Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...... Physico-chemical characterization of anhydrous D-mannitol. J. Therm. Anal. Calorim. 95 (3), 871–876. https://doi.org/10.1007/510973-008-9384-5, Divović Matović, B., Knutson, D., Mitrović, J., Stevanović, V., Stanojević, B., Savić, S., 'Cook, J.M., Savić, M.M., 2022. Behavioural interaction of pyrazoloquinolinone ...
... Dobričić, V.D., Čalija, B.R., Cook, J.M., Savić, M.M., Savić, S.D., 2020. Nanocrystal dispersion of DK-I-56-1, a poorly soluble pyrazoloquinolinone positive modulator of 6 GABAA receptors: formulation approach toward improved in vivo performance. Eur. J. Pharm. Sci. 152, 105432 https://doi.org/10 ...
... 106557 |__|z-ave(nm) m PDI • RDI(%) +++ ++ 300 - *** *** C0.5 - 100 | • • š | • ++ || |- 90 250 *** [ F-0.4 | 80 | + H || *** f |- 70 200 -| . + * | —~ -03 L —~ E J • • ii 60 E\Ž =aso J · | Olsa& Ć " |EE:7 o | š F-0.2 L40 M 00 J · š " } LJ LI | [3 50 | -0.1 L20 J F | 10 01—+—0 ...Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study" in European Journal of Pharmaceutical Sciences, Elsevier BV (2023). https://doi.org/10.1016/j.ejps.2023.106557
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Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach
Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...... [CrossRef] 17. Wu, L.; Zhang, J.; Watanabe, W. Physical and chemical stability of drug nanoparticles. Adv. Drug Deliv. Rev. 2011, 63, 456–469. [CrossRef] 18. Li, J.; Wang, Z.; Zhang, H.; Gao, J.; Zheng, A. Progress in the development of stabilization strategies for nanocrystal preparations. Drug Deliv ...
... Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić Дигитални репозиторијум Рударско-геолошког факултета Универзитета у Београду [ДР РГФ] Overcoming the Low Oral Bioavailability of Deuterated ...
... Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić | Pharmaceutics | 2021 | | 10.3390/pharmaceutics13081188 http://dr.rgf.bg.ac.rs/s/repo/item/0005481 Дигитални репозиторијум Рударско-геолошког ...Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188
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Hidrogeoekološki aspekti aksploatacije uglja u Pelagonijskom basenu (Makedonija)
Kostadin J. Jovanov (2016-06-24)Leţišta uglja „Suvodol“, „Brod-Gneotino“ su u eksploataciji, a leţište uglja „Ţivojno“je u fazi pripremi. Nalaze se u krajnjem jugoistočnom i juţnom delu Pelagonijskekotline. Sva tri leţišta stvorena su u neogenim sedimentima u jezerskim uslovimasedimentacije u zoni kontakta sa prekambrijumskim kristalastim stenama. Kod sva trileţišta ugalja se javljaju više slojeva različite debljine, u okviru kojih se nalaze klastičnisedimenti (gline, peskovi i dr.). U podini ugljenog basena nalaze se kristalaste steneprekambrijumske starosti.Teren u okolini leţišta uglja karakteriše se umereno kontinentalnom klimom, ...ugalj, podzemne vode, površinske vode, neogeni kompleks, izdani,transmisibilnost, nivo podzemne vode, sniţenje nivoa... LEŽISTE ОСТЈА "BROD-GNEOTINO" 1:10 000 — Z _7 оИ 07 o/ 7 o/A O NAODPRO NN о У ~ –/о·/// о о о NRO NRO NRO VA ON — O OOO J J KO O NR 77 оР р -. : ; 29 Хуо o 2 49 ПРУРИ оИ о о 2И о O7 оТ o/pf оЖ о о NRO O SRO O O SRO SRO N o\\\Ko\\o\pp\\\o NRO O HOO Z OZA š///o///o///o///o// 77 a ŠO XO ...
... i gasa CO2 leţišta „Lozišta“ u selu Logovardi kod Bitolja. Kostadin J. Jovanov Doktorska Desertacija 51 Z. Ilijovski i saradnici (2012) projektuju i izvode 19 istraţno-eksploatacionih ...
... podzemnih voda Izdašnost bušotine N0 Z (mnm) NPV (m) Q (l/s) F-22 542,30 - - F2-22 543,07 +3,05 0,22 G-22 544,90 - 0,50 F-20 538,89 - - H2-16 539,85 - - G-18 543,40 +0,50 0,30 G2-18 541,41 +1,70 0,16 G2-22 544,58 - 0,15 Kostadin J. Jovanov ...Kostadin J. Jovanov. "Hidrogeoekološki aspekti aksploatacije uglja u Pelagonijskom basenu (Makedonija)" in Универзитет у Београду, Универзитет у Београду, Рударско-геолошки факултет (2016-06-24)
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Curcumin nanonization using an alternative small-scale production unit: selection of proper stabilizer applying basic physicochemical consideration and biological activity assessment of nanocrystals
Ines Nikolić, Jelena Antić-Stanković, Dragana Božić, Danijela Ranđelović, Bojan Marković, Dominique Jasmin Lunter, Aleksandar Kremenović, Miroslav Savić, Snežana Savić (2020)As the number of poorly soluble drugs is increasing, nanocrystals have become very interesting due to wide range of application possibilities. Curcumin was used as a model active ingredient in this work. Even though it has many proven positive effects, due to its physicochemical issues, its possibilities have not been fully exploited. The goal of this work was to select optimal conditions for a top-down method for curcumin nanosuspension production, and to perform their comprehensive characterization applying complementary methodologies: ...Ines Nikolić, Jelena Antić-Stanković, Dragana Božić, Danijela Ranđelović, Bojan Marković, Dominique Jasmin Lunter, Aleksandar Kremenović, Miroslav Savić, Snežana Savić. "Curcumin nanonization using an alternative small-scale production unit: selection of proper stabilizer applying basic physicochemical consideration and biological activity assessment of nanocrystals" in Review on advanced materials science, Walter de Gruyter GmbH (2020). https://doi.org/10.1515/rams-2020-0043
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Techno-economic assessment of cost-effectiveness of Boron minerals exploitation
Vidanović Nebojša, Tokalić Rade, Ognjanović Sasa, Savić Ljiljana, Savić Ljubinko. "Techno-economic assessment of cost-effectiveness of Boron minerals exploitation" in Technics Technologies Education Management / TTEM 6 no. 4, Sarajevo, Bosnia & Herzegovina:DRUNPP, Sarajevo (2011): 1053-1057
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Spektralni sastav seizmičkih talasa pobuđenih različitim dinamičkim izvorima
Aleksandra Savić (1993)Aleksandra Savić. Spektralni sastav seizmičkih talasa pobuđenih različitim dinamičkim izvorima, Beograd:Rudarsko-geološki fakultet, 1993
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Uticaj tehničkih parametara na brzinu udarnog bušenja u različitim stenskim sredinama
Ljubinko Savić (1992)Ljubinko Savić. Uticaj tehničkih parametara na brzinu udarnog bušenja u različitim stenskim sredinama, Beograd:Rudarsko Geološki Fakultet, 1992
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Prognoza operativne efikasnosti aktivnog podzemnog rudnika zasnovana na teoriji sivih sistema
Svetlana M. ŠTRBAC-Savić (2016)Svetlana M. ŠTRBAC-Savić. Prognoza operativne efikasnosti aktivnog podzemnog rudnika zasnovana na teoriji sivih sistema, Beograd:Rudarsko Geološki Fakultet, 2016
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Uticaj najvažnijih parametara dleta kod udarnog bušenja na brzinu izrade minske bušotine za uslove rudnika Žuta prlina
Ljubinko Savić (1989)Ljubinko Savić. Uticaj najvažnijih parametara dleta kod udarnog bušenja na brzinu izrade minske bušotine za uslove rudnika Žuta prlina, Beograd:Rudarsko-geološki fakultet, 1989
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Possibilites of manifold utilisation of Mataruska banja spa thermomineral waters
Savić Nevena, Milenić Dejan, Krunić Olivera. "Possibilites of manifold utilisation of Mataruska banja spa thermomineral waters" in Spa Congress with international participation 1, Vrnjačka banja:Udruzenje banja Srbije (2010): 182-189
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Petrology of Plagiogranite from Sjenica, Dinaridic Ophiolite Belt (Southwestern Serbia)
Milovanović Dragan, Srećković Batoćanin Danica, Savić Marija, Popović Danica. "Petrology of Plagiogranite from Sjenica, Dinaridic Ophiolite Belt (Southwestern Serbia)" in Geologica Carpathica 2 no. 63, Bratislava: (2012): 97-106. https://doi.org/10.2478/v10096-012-0008-4
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Forecast of a possible climate impact on the water balance and regime in the area of Zlatibor Mountain, Serbia, Europe
Milenić Dejan, Savić Nevena (2014)Milenić Dejan, Savić Nevena. "Forecast of a possible climate impact on the water balance and regime in the area of Zlatibor Mountain, Serbia, Europe" in Proceedings of the 10th International Hydrogeological Congress, Thessaloniki, Greece (2014): 487-494
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Bacteriological pollution of karst springs in Zlatar, Western Serbia
Milenić Dejan, Milanković Đuro, Savić Nevena, Doroslovac Nenad. "Bacteriological pollution of karst springs in Zlatar, Western Serbia" in Proceedings of the 22nd International Karstological School “Classical Karst” Karst and microorganisms, Postojna, Slovenia, Postojna:Karst Research Institute ZRC SAZU (2014): 54-55
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Technological Model of Coal Deposit - base for Mine Production Planning
Gligorić Zoran, Gligorić Miloš, Štrbac-Savić Svetlana. "Technological Model of Coal Deposit - base for Mine Production Planning" in 2nd Virtual International Conference on Science, Niš:Research and Development Center ALFATEC (2016)
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Parameter determination of soil oscillation law in limestone
Lutovac Suzana, Trajković Slobodan, Katona Orsolja, Savić Ljubinko, Leković Branko. "Parameter determination of soil oscillation law in limestone" in Technics Technologies Education Management / TTEM 7 no. 1, Sarajevo:Drunpp (2012): 376-383
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Justification of renewed coal exploitation from the deposit “Bajovac“
Vidanović Nebojša, Tokalić Rade, Savić Ljubinko, Lutovac Suzana. "Justification of renewed coal exploitation from the deposit “Bajovac“" in Mining and Metallurgy Engineering Bor 2013 no. 3, Bor, Serbia:Mining and Metallurgy Institute Bor (2013): 81-89
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Optimization of ring blasting in sublevel stoping gold mine
Duranović Miodrag, Đokić Nemanja, Lapčević Veljko, Torbica Slavko, Petrović Milenko, Savić Ljiljana (2018)Duranović Miodrag, Đokić Nemanja, Lapčević Veljko, Torbica Slavko, Petrović Milenko, Savić Ljiljana. "Optimization of ring blasting in sublevel stoping gold mine" in Podzemni radovi no. 33, :Unierzitet u Beogradu - Rudarsko-geološki fakultet (2018): 61-68
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Basic rocks from the Povlen mountain as a building material
Srećković Batoćanin Danica, Savić Marija, Matović Nenad, Munjas Branko, Mladenović Mališa. "Basic rocks from the Povlen mountain as a building material" in Proceedings, 1st International Conference “HARMONY OF NATURE AND SPIRITUALITY IN STONE”, 17-18 March 2011, Kragujevac, Kragujevac:Stone Studio Association (2011): 185-199
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Integrated menagment od karstic waters-a case stydy of the Zlatibor mountain masiff, Serbia
Milenić Dejan, Milanković Đuro, Petrić Metka, Savić Nevena, Vranješ Ana. "Integrated menagment od karstic waters-a case stydy of the Zlatibor mountain masiff, Serbia" in Global NEST Journal 16 no. 4, Aegean, Greece:University of Aegean (2014): 717-731