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290 items

  • Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach

    Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)
    Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...
    pyrazoloquinolinones, nanocrystals, wet media milling, fasted/fed bioavailability
    ... was used instead of SD. After checking the normality of distribution, the statistical analysis involved Student’s t-test for two sets of results or ANOVA with Turkey HSD as a post hoc test for three results groups. Statistical analysis was performed using IBM SPSS Statistics software (v. 25). p < 0.05 ...
    ... similar to the ones in the corresponding suspensions (p = 0.563 and 0.965 for F5 vs. S5, and F6 vs. S6, respectively, Student t-test) except in the case of F9 (p < 0.01, Student t-test). In this formulation, the solubility of DK-I-60-3 in 0.1 M HCl was surprisingly high. The highest solubility in phosphate ...
    ... Student t-test). In investigated solid tissues, although average values of AUC seem to be different, even two times higher in the group of fed animals, statistically the differences were not significant (p = 0.933, 0.484, and 0.719 for brain, liver, and kidney, respectively, Student t-test), due to ...

  • Математика 2

    Драган Станков (2020)
    математичка анализа

  • Збирка решених задатака из Mатематике I

    Драган Станков (2016)
    линеарна алгебра, аналитичка геометрија, векторски рачун

  • Distant Reading in Digital Humanities: Case Study on the Serbian Part of the ELTeC Collection

    Ranka Stanković, Cvetana Krstev, Branislava Šandrih Todorović, Duško Vitas, Mihailo Škorić, Milica Ikonić Nešić (2022)
    In this paper we present the Serbian part of the ELTeC multilingual corpus of novels written in the time period 1840-1920. The corpus is being built in order to test various distant reading methods and tools with the aim of re-thinking the European literary history. We present the various steps that led to the production of the Serbian sub-collection: the novel selection and retrieval, text preparation, structural annotation, POS-tagging, lemmatization and named entity recognition. The Serbian sub-collection was published ...
    Corpus, Distant Reading, Digital Humanities, Linked Data, Named Entity Recognition, Text Analytics

  • Parallel Bidirectionally Pretrained Taggers as Feature Generators

    Ranka Stanković, Mihailo Škorić, Branislava Šandrih Todorović (2022)
    In a setting where multiple automatic annotation approaches coexist and advance separately but none completely solve a specific problem, the key might be in their combination and integration. This paper outlines a scalable architecture for Part-of-Speech tagging using multiple standalone annotation systems as feature generators for a stacked classifier. It also explores automatic resource expansion via dataset augmentation and bidirectional training in order to increase the number of taggers and to maximize the impact of the composite system, which ...
    анотација, обрада природног језика, издвајање обележја, композитне структуре, врста речи

  • An aproach to Implementation of blended learning in a university setting

    Ivan Obradović, Ranka Stanković, Olivera Kitanović, Jelena Prodanović (2011)
    ... content, goals, outcome, as well as the basic course materials, and dynamic data – information on all important events during the course: results of test and activities, various announcements, additional course materials added by teachers, etc. In the initial phase of portal development the basic ...
    ... more appropriate to the course. Besides course materials, teachers have the possibility of posting various announcements related to their course, test and exam results, examples of previous tests or lists of oral exam topics, links to internal or external resources, etc. Figure 1: FMG CMS ...
    ... available. This gives them the opportunity to get prepared for a forthcoming instruction class, download course materials or get informed about their test and exam results, date and time of forthcoming tests and exams, etc., without being physically present in the FMG building. Course materials ...

  • Parametri zbijanja komunalnog otpada određeni različitim laboratorijskim metodama

    Jovana M Janković Pantić, Dragoslav R Rakić, Irena G Basarić Ikodinović, Tina D Đurić, Snežana Bogdanović (2021)
    Zbijanje komunalnog otpada predstavlja jednu od osnovnih faza korišćenja komunalne deponije. Zbog toga je kao i kod drugih nasutih građevina, veoma korisno odrediti parametre zbijanja: maksimalnu suvu zapreminsku težinu (dmax) i optimalnu vlažnost (wopt). Dobijeni rezultati mogu da posluže prilikom projektovanja kapaciteta deponije kao i prilikom definisanja obradivosti otpada. U dosadašnjoj praksi najčešći način određivanja parametra zbijanja je standardna metoda (Proktorov opit) koja se koristi u mehanici tla, uz eventualnu redukciju energije zbijanja. Međutim, različiti tretmani komunalnog otpada na ...
    deponija komunalnog otpada, zbijanje, Proktorov opit, malj sa šiljcima
    ... workability of waste. In current practice, ће most common method ог determination compaction parameters is by standard method (Proctor compaction test) used јп soil mechanics, with еуепша! reduction of compaction епегру. Although this methodology is accepted in some younger scicntific discipline ...
    ... and cffect of ће wastc composition on compaction conditions is determined. Кеу words: municipal waste landfill, compaction, Proctor compaction test, ћаттег with spikes 1. UVOD Odlaganje komunalnog otpada па deponije predstavlja jedan od vclikih izazova današnjicc sa ckološkog aspekta. Počevši ...

  • Geoenvironmental Investigations at a Smelter Location in Bor (Serbia)

    Petar Papić, Zvonimir Milijić, Jana Stojković, Jovana Milosavljević, Maja Todorović, Marina Ćuk, Željko Kamberović (2014)

  • The Newton method for solving nonlinear equations based on aggregation operators

    Nebojša M. Ralević, Dejan Ćebić (2019)

  • Clockwise vertical-axis rotation in the West Vardar zone of Serbia: Tectonic implications

    Vesna Lesić, Emo Márton, Violeta Gajić, Dragana Jovanović, Vesna Cvetkov (2018)
    The Vardar-Tethyan mega-suture between the Eurasian and Adria (Gondwana) margins comprises remnants of oceanic lithosphere of Neotethys and distal parts of the adjacent continental margins including unconformable Late Cretaceous sedimentary cover and Cenozoic igneous rocks of post-obduction age. This study provides kinematic constraints for displacements and rotations affecting the Serbian part of the West Vardar and Jadar-Kopaonik units after the closure of the Neotethyan (= Sava) Ocean. The targets of the paleomagnetic research were Late Cretaceous sediments representing an ...
    Paleomagnetism, Clockwise rotation, Dinarides, West Vardar zone
    ... classification of reversal test (McFadden and McElhinney 1990); VGP: Virtual Geomagnetic Pole; Lat. N, Long. E: latitude and longitude of the Virtual Geomagnetic Pole, respectively. The tilt-test (Enkin 2003) is negative for the Cretaceous sediments Fig. 8 Regional tilt test for Cretaceous sediments ...
    ... reversal test (McFadden and McElhinny 1990) is positive (Table 4). These features characterize ,,ancient‘‘ magneti- zations, which are not necessarily primary, but were acquired while the tectonic unit remained in the same orientation at the same latitude. The more powerful tilt test (Enkin 2003) ...
    ... Dimitrijević, M. D. (1997). Geology of Jugoslavia (p. 187). Beograd: Geoinstitut-Barex. Enkin, R. (2003). The direction-correction tilt test: An all-purpose tilt/fold test for paleomagnetic studies. Earth and Planetary Science Letters, 212, 151–166. Filipović, I., Pavlović, Z., Marković, B., Rodin ...

  • Specific electrical conductivity in epikarst groundwater of the eastern Suva Planina mt.

    Branislav Petrović (2022)
    The epikarst is a part of the karst outcrop that is located within the unsaturated zone and represents a complex point of contact and mixing of unconsolidated material from the terrain surface. The correct and complete perception of epikarst, its degree of development and the presence on the limestone terrain can be achieved with a multidisciplinary approach. The study area for the applied multidisciplinary research was the Eastern part of karst massif Suva Planina Mt. One important part of ...
    epikarst, specifična električna provodljivost, Suva Planina, pećina Peč

  • Estimating hydraulic parameters for the complex hydrodynamic models

    Dušan Polomčić, Dragoljub Bajić, Jelena Ratković, Bojan Hajdin (2018)
    Hydrodynamic models have usually been calibrated manually, by trial-and-error, with different values of hydraulic parameters and hydraulic characteristics of boundary conditions. This method of calibration and estimation of hydraulic parameters requires an extensive knowledge and experience of experts, but whether the resulting solution includes an optimal set of parameters still remains an open question. An optimization method founded upon the Gauss-Marquardt-Levenberg algorithm, along with PEST software based on that algorithm, introduces automation of model calibration with regularization, which substantially ...
    kalibracija, optimizacija, PEST, koeficijent filtracije

  • The subthermal potential of karstic groundwater of Kučaj–Beljanica region in Serbia estimated by the multivariate analysis

    Ljiljana Vasić, Dragana Ž. Živojinovic, Vladana Rajaković-Ognjanović, Huang Fen, Cao Jianhua (2021)
    Earth-Surface Processes, Geology, Pollution, Soil Science, Water Science and Technology, Environmental Chemistry, Global and Planetary Change

  • Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases

    Nikola Stevanović, Aleksandar Mijatović, Aleksandar Lolić, Mario Zlatović, Rada Baošić (2021)
    Ispitivani su uticaji primene mono- i dvokomponentnih organskih modifikatora na određivanje lipofilnosti 12 tetradentatnih Šifovih baza metodom reverzno-fazne tankoslojne hromatografije. Osnovni cilj je da se proceni tip interakcije između posmatranih jedinjenja i komponenti primenjenih hromatografskih sistema i uspostavi neki obrazac ponašanja kako bi se lakše izabrala kombinacija organskih modifikatora koji će simulirati interakciju u biološkim sistemima na osnovu činjenica da iste osnovne intermolekularne interakcije su odgovorne za ponašanje supstanci i u biološkom i u hromatografskom sistemu. Primenjeni organski modifikator ...
    Šifove baze, Lipofilnost, RP-TLC, Organski modifikatori

  • Correlability of Solar Wind with Seismic Events in the Balkan Peninsula Zone

    Filip Arnaut, Dejan Vučković, Ivana Vasiljević, Vesna Cvetkov (2021)
    The Solar Heliospheric Observatory (SOHO) satellite was launched on the 2nd of December 1995 at L1 Lagrange point (1.5×106 km from Earth) with the purpose of gathering data for helioseismology, remote sensing of the solar atmosphere, and solar wind in situ. The satellite was positioned into orbit in early 1996, with data acquisition expected to commence on January 20th. The correlation between increased values of solar wind parameters and earthquakes in the Balkan peninsula zone between 1996 and 2018 ...
    предвиђање потреса, соларни ветар, статистичка валидација узрочника потреса

  • Analysis of the correlation between modified secondary and primary compression index on the example of old municipal waste in Serbia

    Dragoslav Rakić, Irena Basarić Ikodinović, Jovana Janković, Tina Đurić (2022)
    The paper presents the results related to the determination of the index of primary and maximum and minimum indices of secondary compression, i.e. modified primary and secondary compression indices (Cc, Cc', C'min, C'max), obtained by laboratory testing of artificially prepared municipal waste samples (three series of 9 samples in total) in an oedometer apparatus with a diameter of 20 cm. Old municipal waste was used, which was taken from two landfills in Serbia, one that is ...
    municipal solid waste, secondary compression index, ratio of modified secondary and primary compression index

  • The shear strength evaluation of rough and infilled joints and its indications for stability of rock cutting in schist rock mass

    Dušan Berisavljević, Zoran Berisavljević, Svetlana Melentijević (2022)
    Construction of E75 highway section through Grdelica gorge was one of the most demanding projects realized in recent Serbian history. The alignment approximately 25 km long consists of several tens of bridges, two tunnels, three galleries and cuts with total length of 6 km. The alignment passes through highly anisotropic Palaeozoic schist rock formation of different weathering grades. This study focuses on shear strength properties of discontinuities, which are found to be the critical feature contributing to the occurrence ...
    Diskontinuitet, nelinearni kriterijum loma, anizotropija, hiperbolična anvelopa

  • Pregled hidrogeoloških istraživanja novootkrivenih ležišta metaličnih mineralnih sirovina na prostoru Srbije

    Nebojša Atanacković, Vladimir Živanović, Veselin Dragišić, Sava Magazinović, Jakov Andrijašević (2022)
    Rastuća potražnja za mineralnim sirovinama, zavisnost evropske industrije od njihovog uvoza, kao i otvaranje tržišta u zadnjih 20-ak godina bili su pokretač intenzivnih istraživanja ležišta mineralnih sirovina na području Srbije. Ova istraživanja za rezultat su imala otkriće važnih ležišta bora i litijuma „Jadar“ i „Valjevo“, sedimentnih ležišta zlata „Bigar i Korkan“ i bakra i zlata „Čukaru Peki“. Sastavni deo ovih aktivnosti, posebno u okviru značajnijih novootkrivenih metaličnih ležišta, bila je hidrogeološka karakterizacija ležišta i okolorudnih terena. U razmatranom periodu ...
    rudnička hidrogeologija, rudničke vode, metalična ležišta, podzemne vode, Srbija

  • Some examples of interactions between certain rare earth elements and soil

    Zlatko Nikolovski, Jelena Isailović, Dejan Jeremić, Sabina Kovač, Ilija Brčeski (2021)
    Freundlich adsorption isotherm, sequential extraction, metallic ions, ICP-OES
    ... flasks and were filled up to the line as well as blank test. The sediments were transferred to the initial bottles. Phase III: to each soil from Phase II, 50 mL of 0.4 mol L-1 oxalic acid and 0.4 mol L-1 ammonia oxalate was added. The control test was made up of the extraction solutions. At rotational ...
    ... determined by volumetric method15 and the clay content by hydrometric method.16 Sorption capacity for all three soil types has been determined. Table I. Test conditions for samples on the difractometer. Operating voltage, kV 40 Current, mA 30 X-ray radiation from the copper (Cu) anticathode, Wavelength ...
    ... at rotational shaker with 100 mL of 1 mol L-1 ammonia-acetate solution each. The pH value of obtained suspensions amounted to about 7. The control test was formed of 100 mL extraction agent. Extraction at rotational shaker lasted for two hours. Upon extraction the samples were left to age for 12 hours ...

  • Mikroelementi u uljnim šejlovima Aleksinca i njihov uticaj na životnu sredinu

    Nikoleta Aleksić (2021)
    ... distribuciju, korišćena je jednosmerna ANOVA praćena Tukey-evim HSD post-hoc testom. U suprotnom, korišćen je Kruskal-Wallis H testa praćen Mann-Whitney U testom. Korelacije su ispitane korišćenjem Spearman-ovog korelacionog testa rangova. Obrada podataka vršena je u programu STATISTICA Software Package ...
    ... je praćenjem izluživanja teških metala primenom različitih testova izluživanja: dinamički test DIN 3841-4 S4, Toxicity Characteristic Leaching Procedure-TCLP i California Waste Extraction-WET test. Na osnovu rezultata primenjenih testova izluživanja, pomenute smeše su se pokazale kao neopasan otpad ...
    ... različitim slovima u istom redu ukazuju na statistički značajne razlike (Mann-Whitney U test, p ≤ 0,05 ili Tukey HSD post-hoc test, p ≤ 0,05). * Statistički značajne razlike između veštačkih jezera (Kruskal-Wallis H test, p ≤ 0,05 ili jednosmerna ANOVA p ≤ 0,05). ** Koncentracije iznad granica detekcije ...